Todd Payten’s Cowboys have welcomed back a host of troops for their clash against the Knights, with five stars slotting in.
Harrison Edwards, Jordan McLean, Karl Lawton, Tom Mikaele and Viliami Vailea all rejoined North Queensland’s starting 17.
Meanwhile, the Knights have unveiled a fresh debutant at fullback.
MATCH CENTRE: North Queensland Cowboys vs Newcastle Knights live scores, teams
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Connor Votano, 19, makes his NRL debut, with Dane Gagai shifting to the centres and Fletcher Hunt dropping out of the side.
Phoenix Crossland has also been sidelined due to a head knock, while Tyson Gamble is out for the season due to several facial fractures suffered in NSW Cup.
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